Abstract
Summary
(1) The extent of biochemical alteration in experimental bowel obstruction shock was related directly and consistently to actual rectal temperatures developed, in both normothermic control rats and those made poikilothermic by chlorpromazine. (2) The value of hypothermia in protecting rats from bowel shock has been demonstrated. (3) Chlorpromazine was beneficial in shock only when its use led to enhancement of hypothermia. Its use at a higher environmental temperature facilitated development of hyperthermia, and aggravated the biochemical syndrome of bowel shock. Chlorpromazine appears to have no specific protective action against shock. (4) Possible mechanisms are discussed.
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