Abstract
Summary
1) The effect of a preexisting state of hyperthyroidism and of hypothyroidism on plasma lipid changes occurring during development of experimental nephrotic syndrome was studied in rats. Conversely, the effect of excess thyroid administration on plasma lipids of rats with previously established nephrotic hyperlipemia was studied. 2) Under present experimental circumstances, acute administration of excess thyroid hormone, orally, parenterally or intravenously in a preformed protein binding, did not significantly affect the elevated plasma lipids of nephrotic rats. On the other hand, the rise of plasma lipids occurring during development of nephrotic state in rats was markedly augmented in presence of preexisting hyperthyroidism, and conversely, was considerably slowed by prior induction of an hypothyroid state. The mechanism of these responses was briefly discussed.
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