Abstract
Summary
The influence of cortisone, Medrol (δ1-6α-methylcortisol), and Aristocort diacetate (16α-hydroxy-9α-fluorocortisol-16α, 21 diacetate) administration on serum antitryptic activity, at either 1 or 4 μg/g body weight, was studied in normal, hypophysectomized and adrenalectomized rats. The most consistent elevations of antitryptic activity were demonstrated with Aristocort diacetate administration. Medrol proved to be quite effective, while cortisone induced changes were apparent only at the higher dosage levels. The low serum antitryptic activity observed after hypophysectomy when compared with adrenalectomy would indicate that in addition to the pituitary-adrenal cortex axis other endocrine systems may be involved in the physiological control of the fibrinolytic system.
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