Abstract
Conclusion
An increased rate of aldosterone production after induction of aminonucleoside nephrosis in rats has been confirmed. After short term treatment with cortisone acetate, at the dose level of 350 and 500 μg/day, corticosterone production of both normal and nephrotic animals was decreased to one-third of their respective controls. Cortisone reverted the increased aldosterone secretion of nephrotic rats to normal, this was accompanied by marked loss or even total disappearance of ascites.
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