Abstract
Summary
Basic dose response curves for estrone, estradiol, and estriol were established using uterine weight method in immature female rats of the Sherman strain. Combinations of estrone + estriol; estrone + estradiol; and estradiol + estriol were set up to study their effect on stimulation of the immature rat uterus. The interpretations were based on the data of dose response curves. A synergistic effect was observed in all of the mixtures studied in the low dose level except with the mixture of estrone + estradiol, which showed it in the higher dose levels. A combination of estrone + estriol resulted in synergism being observed for 3 out of the 5 mixtures studied up to a 5γ dose level. Estriol did not inhibit estrone activity in any of the mixtures. In the study of the 3 estradiol + estriol mixtures there was evidence of inhibition of estradiol by estriol in only one of the mixtures. The manner of action of these combinations of estrogens has been postulated.
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