Abstract
Summary
A serial study was made of protein and glycoprotein changes of swine during arthritis which follows recovery from Erysipelothrix infections. As in sera from humans with rheumatoid arthritis, elevated serum glycoprotein, seromucoid and serum globulins and lowered serum albumin concentrations were noted in swine sera during active phases of the disease. No serum α1-globulin was identified in swine sera. During remissions of experimental arthritis, serum glycoprotein levels decreased and the serum albumin increased. Cortisone treatment of animals with active arthritis produced clinical improvement accompanied by striking increases of albumin protein with decreases of seromucoid, serum γ-globulin protein and γ-globulin bound hexose concentrations.
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