Abstract
Conclusions
Tech. DDD, recrystalized DDD, supernatant mother liquor of Tech. DDD, and Tech. Perthane cause prolonged sleeping time in dogs given sodium pentobarbital. This increased sleeping time is not seemingly related to atrophy of adrenal cortex, and the very slight amount of fatty change in the liver does not cause prolonged clearance of barbiturates from the blood. This prolonged sleeping time is not obtained with similar doses of Tech. DDD in the rat although a slight lowering of tolerance to anoxia may result.
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