Abstract
Summary
Simultaneous intraluminal pressure and pH recordings at various levels within the esophagus and stomach were performed in 90 subjects. Evidence of esophageal inflammation was present in 52 of 54 individuals manifesting gastroesophageal acid regurgitation but was absent in all of those with normal records. A zone of increased pressure at the diaphragmatic hiatus could not be correlated with presence or absence of acid reflux. The evidence suggests that reflux of gastric contents is important in pathogenesis of esophagitis.
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