Abstract
Summary
1. Storage of pyrimethamine or active products of pyrimethamine occurs in tissue cultures of monkey kidney treated with the drug. This has been demonstrated by parasite challenges of treated cultures and by microbiological assay with Streptococcus faecalis R. 2. The limits of this storage phenomenon have been defined. 3. Some differences in storage of pyrimethamine were noted in monkey kidney cells of various ages. 4. Chick embryo heart explants. HeLa cells and human intestinal cells are able to store pyrimethamine in levels inhibitory to parasite. 5. Mouse mince cultures and KB cells possess a slight ability to store pyrimethamine. 6. Conjunctival epithelium (Chang) shows no evidence of drug storage.
Get full access to this article
View all access options for this article.