Abstract
Summary
1. A significant cardiac anti-accelerator activity was found among members of a new synthetic series of polymerthoxyphenyl amines. 2. When tested on the isolated, epinephrine driven rabbit heart their potency was found in several instances to be comparable to that of veratramine. 3. They could produce also cardiac slowing in anesthetized and unanesthetized dogs as well as block, in unanesthetized dogs, compensatory tachycardia due to administration of a sympatholytic. 4. Some of the compounds were found to be coronary dilators, in one case 2-3 times more potent than papaverine. 5. Since the polyphenyl compounds were found not to be sympatholytic or adrenolytic, since their action is extra-vagal and independent of their local anesthetic activity, the possibility is suggested they have a specific site of action at the “primitive” pacemaker receptor.
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