Relative Lack of Pharmacologic Action of 3-Methoxy Analogue of Norepinephrine. ∗

Abstract

Conclusions

Normetanephrine is inert as regards those aspects of central nervous system activity which have been studied in cats, and is a relatively weak pressor agent in the dog. An intravenous dose of 5 mg was inactive with regard to circulatory and psychological effects in man. Although a more detailed study of this compound should be done, the findings presented strongly suggest that O-methylation at the 3 position is an effective means of inactivating norepinephrine. It will be of interest to investigate the enzymatic mechanisms involved in this unusual methylation process and to attempt to alter it in vitro and in vivo.