Abstract
Summary
Action of the loose connective tissue (90% of cells are fibroblasts) on Cortisol was investigated. Data are presented on the isolation and identification of 5 of the 7 metabolites observed when cortisol-4-C14 was incubated with mouse (AK) loose connective tissue. The identified metabolites are: 20-epi substance E of Reichstein; cortisone; dihydro-cortisol; corticosterone; and 4-androstene, 11-beta-ol, 3, 17-dione. The relationship of this metabolic picture to the fibroblastic role on the anti-inflammatory action of Cortisol is discussed.
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