Effect of Alazopeptin (A) on Litter and Fetus of the Rat in utero.

Abstract

Summary

Alazopeptin had the following toxicity in the adult Long-Evans rat: (1) Single LD₅₀ of 150 mg/kg, the 5 LD₅₀ of .3 mg/kg. (2) Alazopeptin destroyed in utero entire litters of Long-Evans rats (at time of implantation) when given i.p. on 7th and 8th day of gestation in doses of .3 mg/kg. (3) And in doses of .5 mg/kg i.p. (at mid term) when given on 11th and 12th day of gestation. (4) Placental remnants frequently survived the fetuses and were found at term. (5) The lethal dose of A. to the fetus of .5 mg/kg was approximately 1/30 of the LD₅₀ for the mother animal.