Abstract
Summary
Malonate in a concentration (0.03 M) which almost completely blocks the Krebs cycle in muscle mince, has no significant effect on performance of the isolated dog heart (heart-lung preparation) or on its high-energy phosphorus compounds. 0.06 M malonate produces also no change in the phosphorus compounds, there is even a slight increase in phosphocreatine. The double dose of malonate, however, produces a sudden cardiac dilatation before the full amount is administered. This is accompanied by a decrease in heart rate, ECG changes and arrhythmias. Significant increases in heart succinate with both doses constitute presumptive evidence that malonate diffuses into heart muscle but this accumulation of succinate shows variations and it cannot be correlated with cardiac performance.
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