Plasma Ketosteroid in Adrenal-Tumor Bearing Mice. ∗ † ‡

Abstract

Summary

A transplantable adrenal mouse carcinoma produced elevated plasma ketosteroid in the host. Non-tumor-bearing mice subjected to gonadectomy-adrenalectomy have negligible levels of plasma ketosteroid. Tumor-bearing mice have unchanged plasma levels following this procedure indicating steroid production by the tumor. ACTH and Δ1-9α fluorohydrocortisone have no influence on the plasma ketosteroid level of tumor-bearing animals. Distant metastases were found in adrenalectomized-gonadectomized males and adrenalectomized females, but not in animals not subjected to these procedures.