Abstract
Summary
The prothrombin activation cycle consists of a sequence described by the following: Prothrombin (sensitive to calcium + Ac-globulin + lung thromboplastin) → Prothrombin derivative I (not sensitive to calcium + Ac-globulin + lung thromboplastin) → Prothrombin derivative II (sensitive to calcium + Ac-globulin + lung thromboplastin) → Thrombin. Solutions of prothrombin standing at 4°C go through most of this cycle, the prothrombin molecule alone possessing the peculiar properties that enables it to do this.
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