Abstract
Summary
Six imidazolyl-steroids were tested for depressor activity in metacorticoid hypertensive rats. Two compounds were active acutely and chronically: 17β-(4[5]-imidazolyl)-5-androsten-3β-ol and 17α-hydroxy-17 (4[5] -imidazolyl)-4-androsten-3-one. Activity was apparently reduced by methylation of the imidazole ring of the former and by 17-oxidation or 17-dehydroxylation of the latter.
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