Abstract
Summary
Trace amounts of C14-22β-hydroxyprogesterone, C14-progesterone, and C14-DOC were incubated with homogenates of adrenocortical tissue prepared in various media. These homogenates, which synthesize corticoids from endogenous precursors, hydroxylated C14-11β-hydroxyprogesterone at both the C-21 and C-17 positions, producing Cortisol and corticosterone. However, the limited extent of these conversions relative to that of known precursors (progesterone and DOC) indicates that 11β-hydroxyprogesterone is not a major intermediary in the biosynthesis of these corticoids from progesterone.
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