Abstract
Summary
The relation between activity of brain carbonic anhydrase and susceptibility to various grades of seizure patterns has been studied in young rats by observations of the effects of acetazolamide. The percentage inhibition of carbonic anhydrase and of the reaction catalyzed by the enzyme is related to the suppression of tonic and clonic seizure patterns. It is suggested that brain carbonic anhydrase and its specific catalytic activity may be essential for the propagation of the seizure discharge. Low levels of enzyme activity may be sufficient for focal discharge and the induction of minor seizure patterns while a relatively high degree of activity may be required for the propagation of a generalized seizure discharge and the induction of a major tonic seizure.
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