Effect of Phosphorylated Hesperidin and Hyaluronidase on Absorption From Peritoneal Cavity of Rats. ∗

Abstract

Summary

1. The effect of hyaluronidase and phosphorylated hesperidin on absorption of 0.9% NaCl solution from the peritoneal cavity of female rats was studied. 2. Intraperitoneal administration of hyaluronidase increased and administration of phosphorylated hesperidin decreased the net fluid absorption. 3. Hyaluronidase abolished the effect of hesperidin when administered to hesperidin treated animals. 4. Adrenalectomy had no effect on the action of hesperidin. 5. The possibility that the hesperidin decreases the net absorption in untreated animals by direct effect on permeability of the membranes rather than by inhibition of hyaluronidase is discussed.