Abstract
Summary
The appearance of cutaneous bluing and vasodepression has been followed after T-1824 and 48/80 injection in dogs and rats subsequently challenged with polyvinyl-pyrrolidone (PVP) and dextran respectively. The reverse sequence of injection was also tested. Graded doses of 48/80 in dogs resulted in refractoriness to the vasodepressive effects of similar doses, but cutaneous bluing was always seen. This increased skin capillary permeability may be interpreted as evidence of local release of histamine or other substance. In dogs it was confirmed that there was no cross protection between PVP and 48/80. In rats anesthetized with a barbiturate and pretreated with 48/80 the usual vasodepression and bluing after dextran did not occur. Rats refractory to dextran were also refractory to 48/80.
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