Abstract
Summary
(1) A method has been developed by which intraabdominal pressure sufficient to immobilize the liver can be established in small animals laparotomized for the study of the intrahepatic circulation in vivo. (2) In choline-deficient rats there is an accumulation of tiny fat droplets along the sinusoidal walls or overlying them as early as 24 or 36 hours after the ingestion of the deficient diet. The small and barely compressible droplets exert a pressure on the pliable endothelial walls indenting them and impeding the sinusoidal flow. (3) These phenomena are conspicuous on the surface of the transilluminated liver edge which of course is formed by zones 3 of the acini under observation.
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