Further Observations on Effect on Plasma 17-OH-Corticosteroids in the Dog of Derivatives of 2,2-Bis-(p-Chlorophenyl)-1,1-Dichloroethane (DDD,TDE). ∗

Abstract

Summary

1) The effect of 8 derivatives of 2.2-bis-(p-chlorophenyl) − 1,1-dichloroethane (DDD, TDE) on responsiveness of the adrenal cortex to ACTH, as determined by changes in plasma 17-hydroxycorticoids, has been studied in dogs. The following derivatives decreased the corticoid response: those with para-phenyl modifications; bromine substitution of the aliphatic chlorines; hydroxylation on the 2-position of the ethane moiety. No change in response was noted with a derivative in which hydrogen replaced chlorine in the 1-position of the ethane moiety, and with benzophenone, a possible DDD metabolite. Somewhat equivocal results were obtained with an ethylene analogue. 2) The relationship between these biochemical findings and the histopathologic effects recorded for this series of compounds is discussed.