Abstract
Summary
The epithelial primordium of the pituitary in Stage 17 embryos of Rana sylvatica was removed without including or injuring adjacent brain and transplanted into the tail bud of hypophysectomized host embryos of the same stage. Donors and hosts were studied for pigmentary reaction and for histological differentiation of appropriate tissues. It was concluded that the epithelial primordium when it first appears as a morphologically distinct entity is capable of differentiating into both pars anterior and pars intermedia without further contact with brain or other nerve cells. It is likewise concluded that the neurosecretory mechanism of the hypothalamus differentiates normally in the absence of the epithelial pituitary.
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