Studies on in vivo Stability of an Iron Chelate

Abstract

Summary

The Fe⁵⁹ tagged ferric chelate of disodium N-hydroxyethylethylenediamine triacetate was administered to 2 subjects made iron-deficient by repeated phlebotomies. Intramuscular injection in one subject resulted in a rapid uptake from the injection site, early incorporation into circulating RBC, and effective utilization of Fe⁵⁹ by the RBC. Oral and intraduodenal administration of the tagged chelate to the second subject showed that iron in this form was not readily absorbed from the gastrointestinal tract.