Abstract
Summary
It was not possible to induce hyperglycemia in dogs and rabbits with nontoxic doses of histamine injected intravenously, whereas a moderate hyperglycemia occurred in both species when the dose was high enough to produce toxic effects; epinephrine release and glycogenolysis probably resulted from reflex sympathetic activity consequent to the shock induced. Compound 48/80 also did not induce hyperglycemia in rabbits except in those showing toxic symptoms. In the dog, a dose of 48/80 capable of producing severe symptoms, including prostration, caused a moderate fall in blood glucose at a time when histamine shock produced a hyperglycemia. Therefore, compound 48/80 exerted a transient hypoglycemic action in dogs which appears to be unrelated to histamine release.
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