Failure to Sensitize to Autologous Skin. ∗

Abstract

Summary

1) Eighty-nine guinea pigs were injected intracutaneously, intramuscularly or intraperitoneally with autologous skin in emulsion with adjuvants. Thirty-eight guinea pigs were injected intracutaneously or intramuscularly with control emulsion, not containing skin. Subsequently an autograft was done on each animal. No significant differences were noted in acceptance of autografts between animals injected with skin emulsion and control emulsion. 2) Irritancy tests using scraping and burning of the skin did not produce different results in the test animals and the control animals. 3) Under the conditions of these tests no autosensitization to skin could be demonstrated in guinea pigs.