Abstract
Summary
1. From the urine of 4 out of 5 patients with gargoylism, a mixture of mucopolysaccharides was isolated which could be identified as ChS-B and heparitin sulfate—with the former predominating. The urine of one patient, and the liver of another, yielded only heparitin sulfate. 2. The type of polysaccharide excreted by these patients had no obvious correlation with the severity of the disease or the postulated mode of inheritance suggested by the history. 3. It is suggested that gargoylism represents an overproduction of certain mucopolysaccharides due to a genetically determined error of differentiation of fibroblasts.
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