Abstract
Conclusion
Localized cerebral hypothermia has been produced in the dog by an extracorporeal circulation utilizing the carotid arteries and external jugular veins. During the acute stage of perfusion, various parameters of study have been recorded and in general, these results are in accord with those noted in states of generalized hypothermia. Survival is predicated upon low perfusion flows and development of perfusion pressure closely aligned with the systemic arterial pressure. Such long-term survivals allow the further investigation of the effect of various drugs and chemical substances upon the normothermic and hypothermic brain whose circulation is isolated in a measurable manner from the systemic circulation.
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