Abstract
Summary
A modification of the Saffran and Schally technic of in vitro bioassay of ACTH is described and evidence is presented for its precision, validity and reliability. Changes in pituitary ACTH content and concentration in rats after administration of various hormones for one week were studied by means of this technic. ACTH administration and adrenalectomy both resulted in a striking increase in pituitary ACTH content. Epinephrine and cortisone administration were both followed by significant depletion of pituitary ACTH.
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