Creatine Metabolism in Vitamin E Deficiency. ∗

Abstract

Summary

1) Normal and Vit. E-deficient rabbits were killed at varying time intervals after injection of glycine-1-C¹⁴. Concentration and specific activities of kidney glycocyamine, liver creatine, skeletal muscle creatine and heart creatine were determined. Vit. E deficiency led to an elevated concentration of liver creatine, to reduced concentration of skeletal muscle creatine and did not influence the concentration of kidney glycocyamine or heart creatine. 2. The turnover rate of liver creatine and skeletal muscle creatine was increased in Vit. E-deficient rabbits. The turnover rate of heart creatine was considerably greater than the turnover rate of skeletal muscle creatine and was unaffected by Vit. E deficiency. The results show that in Vit. E deficient rabbits, rate of creatine synthesis is increased and turnover rate of skeletal muscle creatine is increased.