Abstract
Summary
The hypothermic effect of dibenamine and pyribenzamine was observed but was found to be of small intensity and short duration compared to that of chlorpromazine. Individually these drugs were found to potentiate the hypothermic effect of chlorpromazine to an extent far greater than could be predicted. Indeed, whereas dibenamine or pyribenzamine caused a drop in rectal temperature of less than 1°C, these drugs injected individually with chlorpromazine potentiated the effect of chlorpromazine on body temperature by 3 to 4°C. However, dibenamine and pyribenzamine antagonize one another when given simultaneously to animals treated with chlorpromazine; this antagonism further illustrates the complexity of action of these drugs.
Get full access to this article
View all access options for this article.