An Effect of Pyridine-2-Aldoxime Methiodide (2-PAM) on Cholinesterase at Motor End-Plates

Abstract

Conclusion

2-PAM in a high concentration in vitro had a dual effect on motor end-plate ChE previously inactivated with TEPP. The oxime reactivated the enzyme and, if allowed to remain in contact with the preparation, inhibited the reactivated enzyme. The effect of 2-PAM was reversible and after the removal of 2-PAM no protection to ChE from the later exposure to TEPP was demonstrated.