Histopathology of Hydrocephalus Resulting from a Deficiency of Vit. B 12 . ∗

Abstract

Summary

Female rats deficient in Vit. B₁₂ produced offspring with a high incidence of hydrocephalus. The cerebral cortex of hydrocephalic brains was decreased in thickness and in some areas the ependyma was missing. Ependymal and choroid cellular morphology was deranged and the cells had accumulated lipide. Tall columnar-type cells normally present as an intact layer in the roof of the third ventricle and aqueduct of control rats were occasionally found in hydrocephalic brains with occluded aqueducts.