Hyperlipoproteinemia and Cholesterol Deposition at the Arteries of I 131 -Treated Dogs. ∗

Abstract

Summary

Dogs maintained for a year after I¹³¹ administration were found to achieve average maintenance levels of serum cholesterol in excess of 430 mg % and comparably elevated concentrations of other serum lipid and lipoprotein parameters. Tissue analysis at autopsy revealed significantly elevated levels of coronary artery, aorta, and liver cholesterol in male treated dogs, as compared with control males. Treated female dogs differed from treated males in developing significantly higher levels of S_f 0–12 blood lipoproteins, and slightly, possibly significantly, lower levels of coronary artery cholesterol. No correlation between altered tissue cholesterol content and any of the serum lipid or lipoprotein moieties was observed.