Abstract
Summary
The daily intramuscular administration of large doses (1 mg/kg) of nine-alpha-fluorohydrocortisone (FF) to intact dogs resulted in a chronic state of polydipsia and polyuria with gross evidence of mild dehydration. With FF treatment the fecal excretion of sodium was reduced and that of potassium enhanced but the converse was true for urinary excretion. These changes did not significantly alter sodium balance although serum sodium was elevated, but resulted in a negative potassium balance which was indicated by a drop in serum potassium and muscular weakness.
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