Abstract
Summary
1) In contrast to previous reports, TOTP was found to be an active inhibitor of true cholinesterase in erythrocytes and brain of rats. Cholinergic signs were noted when activity in either tissue fell to less than 20% of normal. Maximum inhibition occurred 24 hours after single injection and exceeded inhibition of the plasma enzyme. Repeated sublethal doses also produced greater inhibition of true than of pseudocholinesterase. 2) On the other hand, the plasma enzyme was inhibited 24 hours after a single dose of TMTP while the cholinesterase of erythrocytes and brain was not significantly affected. TPTP failed to inhibit the enzyme of any of the 3 tissues. 3) No signs of paralysis were elicited, and no histologic lesions were discovered in the peripheral or central nervous system.
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