Abstract
Summary
1. Carbon monoxide gas and autogenous red cells tagged with Cr51 were administered simultaneously to rabbits and to dogs. Blood and homogenized tissues from various organs were analyzed for radioactivity and for CO content. 2. The volume of distribution of CO was 13% larger than the volume of distribution of Cr51 in the rabbit. The discrepancy is the same as that found in man and the splenectomized dog. 3. CO accumulated in red skeletal muscle and myocardium in amounts sufficient to account for the discrepancy between distribution volumes. 4. Evidence was found pointing to slight accumulation of Cr51 in spleen and lung. Further studies of this phenomenon are described in part II of this report.
Get full access to this article
View all access options for this article.