Abstract
Summary
1) Purified virus was prepared from tissue culture fluids containing Type I (Mahoney and Parker strains), Type II (MEF I strain) and Type III (Saukett strain) poliovirus. 2) The purified viruses were successfully inactivated with formaldehyde and the inactivation kinetics studied. 3) Purified Type I (Mahoney and Parker strains) viruses and the vaccines derived from them were shown to be immunogenically potent in chicks. 4) No statistical difference was found in the immunogenic potency of purified Parker and Mahoney vaccines in the chick. 5) Purified infective Mahoney virus was found to be significantly more potent than Parker virus. 6) Vaccines derived from purified Mahoney and Parker viruses were significantly less potent than the parent viruses.
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