Abstract
Summary
1) Repeated exposure of isolated sections of rabbit ileum to atropine (40 μg%), with washings 10 min after each exposure, results in development of tolerance, such that by sixth or seventh exposure, the depressant effects of atropine on height of spontaneous contraction are minimal or even abolished. The phenomenon of tolerance appears to be associated with gradual accumulation of atropine within the tissue. 2) Repeated exposure of rabbit ileum to adiphenine (1 mg%) results in no observable tendency toward the development of tolerance. Moreover, when adiphenine is applied to ileum which previously has been made tolerant to atropine, adiphenine is fully effective in depressing the height of spontaneous contraction.
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