Abstract
Summary
Experimental alkaptonuria of rats maintained on a high tyrosine diet is associated with an increased ratio of activity of the tyrosine transaminase to activity of the homogentisate oxidase in the liver. This type of alkaptonuria is therefore the result of an adaptive increase in relative rate of homogentisate formation, in contrast to the relative decrease in rate of homogentisate degradation believed to be responsible for hereditary alkaptonuria in man.
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