Abstract
Summary
The toxicity of 3,3-dimethyl-1-phenyltriazene has been described in various laboratory mammals. The agent produced a “neurological” disturbance in mice resembling that seen in the congenitally abnormal “waltzing” or “shaker” strains. In rats lesions were prominent in hematopoietic tissues and in the kidney. In dogs an unusual hepatic lesion was induced which was associated with a variety of disturbances in liver function. The effects of the compound were discussed with respect to possible transformation in vivo into phenyldiazonium and various derivatives of the latter substance. Hepatic insufficiency, renal damage, and hematopoietic depression should be anticipated in clinical trials with the agent.
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