Abstract
Summary
The hypothermic effect of chlorpromazine, serotonin and histamine was investigated in rats at 21°C after acclimatization at 6°C for 1 to 28 days. The response to chlorpromazine was greatly reduced in animals acclimatized to cold for 7 and 28 days. Similarly, the fall in body temperature observed with serotonin and histamine was not as pronounced in acclimatized as in control animals.
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