Abstract
Summary
An in vitro technic has been used to detect the interaction of various basic substances (ACTH, polymyxin, clupein and neomycin) with heparin, an acidic mucopolysaccharide of the tissues. It was observed that substances effectively interacting with heparin in this in vitro system markedly potentiated the toxicity of polymyxin B in vivo. It has been suggested that polymyxin tolerance is dependent on an ion exchange function of heparin-like constituents of the tissues and that the capacity for tolerance can be reduced by substances which have a strong affinity for these heparin-like constituents.
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