Abstract
Summary
Repeated intracarotid injections of warm, sterile, Ringer's solution, carried out under high pressure in control rats, caused transient rises of intra-aortic (lower abdominal) blood pressure, up to 194 mm Hg above the basal level. Thirty rats thus treated failed to show the development of arterial or arteriolar lesions of any kind, in the kidney or any other organ or tissue, when they were sacrificed at the end of 4 days after the completion of the injections. The results of this study fail to confirm the finding of Byrom and Dodson of necrotizing arterial and arteriolar lesions in the kidney as a result of repeated sudden increases of systemic intra-arterial tension, and do not lend support to their contention that elevated blood pressure alone is a sufficient condition for the production of the arteriolar lesions characteristic of malignant hypertension.
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