Abstract
Summary
Virgin female DBA x CE and reciprocally crossed hybrid mice were ovariectomized at 4 to 5, 9 to 12, and 15 to 18 months of age. Two weeks later one-half of the animals in each group were injected with 3 μg of estradiol diproprionate and were sacrificed 48 hours later. The uterine response was calculated by comparing uterine weights (adjusted to mg/g body weight) after estrogen treatment with those in the untreated controls. In the 4 to 5-month-old animals the increment in uterine weight was 336%; in the 2 older groups, 469% and 464% respectively. These data indicate that the uterine hyperplasia which develops spontaneously in these mice after 7 to 8 months of age is due in part to increased uterine sensitivity to estrogen as well as to the hyperestrinism previously known to occur.
Get full access to this article
View all access options for this article.