Abstract
Summary
Rats and mice when given 0.1% and 1.0% solutions of 2-dimethylamino-ethanol (DMAE) to drink for prolonged periods showed either a decrement or no improvement in maze performance. They exhibited increased emotionality as measured by the Stone and Anderson tests. Rats given 160 mg/day were subject to frequent spontaneous epileptiform seizures. Inbred (A-strain) mice when tested for susceptibility to audiogenic seizures showed more intense attacks with shorter latent periods while on DMAE. The decremental effect of DMAE upon maze performance was interpreted as a secondary effect of increased emotionality and/or epileptiform seizures. The facilitatory effect upon audiogenic seizure susceptibility is interpreted as due probably to stimulation of the brain stem reticular formation.
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