Effect of Aureomycin on Hepatic Utilization of Labeled Body Fat in Rats. ∗

Abstract

Summary

Administration of 5 mg Aureomycin to rats, the body fat of which had been labeled previously with C¹⁴-tripalmitin did not result in accumulation of excessive C¹⁴ activity in hepatic fatty acids. The amount and radioactivity of total fatty acids of carcass and of intestine were likewise similar in experimental and control animals. These findings are discussed in relation to the observation that Aureomycin causes an increase in incorporation of C¹⁴-acetate into hepatic fatty acids of rats. A 4-day metabolic balance study showed that from 81 to 93% of the fed tripalmitin was absorbed.