Abstract
Summary
1. An investigation of the influence of BAPN on incorporation of glycine-1-C14 into proteins and nucleic acids of rat croton oil pouches and dermis was undertaken. 2. Incorporation of glycine into protein residues of fibrous tissue from croton oil pouches was decreased about 25% in animals pretreated with BAPN. In protein residues of dermis the rate of incorporation of glycine was also decreased, but to a much lesser degree, about 15%. 3. Studies of the nucleic acid fraction indicate that no change occurs in glycine uptake in fibrous tissue of dermis or croton oil pouches from BAPN treated animals as compared to controls. 4. The results of these experiments suggest that BAPN primarily affects amino acid incorporation into collagen or ground substance rather than the cellular portion of connective tissue.
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