Abstract
Summary
Mumps virus, inoculated into embryonated chicken eggs of 48 hours incubation, produced a high percentage of cataracts in embryos surviving from 3 to 15 days after inoculation. Other defects observed included general growth inhibition, retardation in development of the amnion, mild axis twists, retardation of feathering, defects of the choroid layer of the optic cup and retarded development of the lids and skin around the eye. A decrease in the percentage of embryos showing defects was directly related to a decrease in the titer of the virus inoculated. Virus inoculated into the young embryos was shown to increase in titer over a period of 2 days after inoculation and was recoverable in high titer over a period of at least 5 days. Heat-inactivated mumps virus produced no cataracts or other defects.
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